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A non-blockchain database tends to be easier, faster, cheaper and more efficient; if your business has no need for higher security, transparency, and immutability a non-blockchain database would be preferable.
2.
Increase in the expenses to run and maintain the database, shortage of qualified professionals and tools, slower response in retrieving data and effectuating transactions, impossibility to execute CRUD, less efficient.
3.
If there is no need for decentralization, a blockchain wouldn’t be justified, once you don’t need to trust other writers and sacrifice security.